Cimitidine

Cimitidine Brand names, Cimitidine Analogs

Cimitidine Brand Names Mixture

Lotrisone (clotrimazole + betamethasone)

Cimitidine Chemical_Formula

C₂₂H₁₇ClN₂

Cimitidine RX_link

http://www.rxlist.com/cgi/generic2/clotrimaz.htm

Cimitidine fda sheet

Cimitidine FDA

Cimitidine msds (material safety sheet)

Cimitidine MSDS

Cimitidine Synthesis Reference

K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)

Cimitidine Molecular Weight

344.837 g/mol

Cimitidine Melting Point

147-149 ^oC

Cimitidine H₂O Solubility

29.84 mg/mL

Cimitidine State

Solid

Cimitidine LogP

5.98

Cimitidine Dosage Forms

Cream; Liquid; Solution; Suppository; Ointment; Lozenge

Cimitidine Indication

For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.

Cimitidine Pharmacology

Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.

Cimitidine Absorption

Poorly and erratically absorbed orally, minimal vaginal or topical absorption.

Cimitidine side effects and Toxicity

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.

Cimitidine Patient Information

How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.

Cimitidine Organisms Affected

Yeast and other fungi