Kineret (Amgen Inc)
Kineret (Amgen Inc) Brand names, Kineret (Amgen Inc) Analogs
Kineret (Amgen Inc) Brand Names Mixture
- No information avaliable
Kineret (Amgen Inc) Chemical_Formula
C759H1186N208O232S10
Kineret (Amgen Inc) RX_link
http://www.rxlist.com/cgi/generic/anakinra.htm
Kineret (Amgen Inc) fda sheet
Kineret (Amgen Inc) msds (material safety sheet)
Kineret (Amgen Inc) Synthesis Reference
No information avaliable
Kineret (Amgen Inc) Molecular Weight
17257.6
Kineret (Amgen Inc) Melting Point
No information avaliable
Kineret (Amgen Inc) H2O Solubility
No information avaliable
Kineret (Amgen Inc) State
Liquid
Kineret (Amgen Inc) LogP
-0.412
Kineret (Amgen Inc) Dosage Forms
Solution
Kineret (Amgen Inc) Indication
For treatment of adult rheumatoid arthritis
Kineret (Amgen Inc) Pharmacology
Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.
Kineret (Amgen Inc) Absorption
No information avaliable
Kineret (Amgen Inc) side effects and Toxicity
No information avaliable
Kineret (Amgen Inc) Patient Information
BIOD00060.html
Kineret (Amgen Inc) Organisms Affected
Humans and other mammals
