IL-1ra
IL-1ra Brand names, IL-1ra Analogs
IL-1ra Brand Names Mixture
- No information avaliable
IL-1ra Chemical_Formula
C759H1186N208O232S10
IL-1ra RX_link
http://www.rxlist.com/cgi/generic/anakinra.htm
IL-1ra fda sheet
IL-1ra msds (material safety sheet)
IL-1ra Synthesis Reference
No information avaliable
IL-1ra Molecular Weight
17257.6
IL-1ra Melting Point
No information avaliable
IL-1ra H2O Solubility
No information avaliable
IL-1ra State
Liquid
IL-1ra LogP
-0.412
IL-1ra Dosage Forms
Solution
IL-1ra Indication
For treatment of adult rheumatoid arthritis
IL-1ra Pharmacology
Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.
IL-1ra Absorption
No information avaliable
IL-1ra side effects and Toxicity
No information avaliable
IL-1ra Patient Information
BIOD00060.html
IL-1ra Organisms Affected
Humans and other mammals
