IRAP
IRAP Brand names, IRAP Analogs
IRAP Brand Names Mixture
- No information avaliable
IRAP Chemical_Formula
C759H1186N208O232S10
IRAP RX_link
http://www.rxlist.com/cgi/generic/anakinra.htm
IRAP fda sheet
IRAP msds (material safety sheet)
IRAP Synthesis Reference
No information avaliable
IRAP Molecular Weight
17257.6
IRAP Melting Point
No information avaliable
IRAP H2O Solubility
No information avaliable
IRAP State
Liquid
IRAP LogP
-0.412
IRAP Dosage Forms
Solution
IRAP Indication
For treatment of adult rheumatoid arthritis
IRAP Pharmacology
Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.
IRAP Absorption
No information avaliable
IRAP side effects and Toxicity
No information avaliable
IRAP Patient Information
BIOD00060.html
IRAP Organisms Affected
Humans and other mammals
