ICIL-1RA
ICIL-1RA Brand names, ICIL-1RA Analogs
ICIL-1RA Brand Names Mixture
- No information avaliable
ICIL-1RA Chemical_Formula
C759H1186N208O232S10
ICIL-1RA RX_link
http://www.rxlist.com/cgi/generic/anakinra.htm
ICIL-1RA fda sheet
ICIL-1RA msds (material safety sheet)
ICIL-1RA Synthesis Reference
No information avaliable
ICIL-1RA Molecular Weight
17257.6
ICIL-1RA Melting Point
No information avaliable
ICIL-1RA H2O Solubility
No information avaliable
ICIL-1RA State
Liquid
ICIL-1RA LogP
-0.412
ICIL-1RA Dosage Forms
Solution
ICIL-1RA Indication
For treatment of adult rheumatoid arthritis
ICIL-1RA Pharmacology
Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.
ICIL-1RA Absorption
No information avaliable
ICIL-1RA side effects and Toxicity
No information avaliable
ICIL-1RA Patient Information
BIOD00060.html
ICIL-1RA Organisms Affected
Humans and other mammals
