Idarubicin
Idarubicin Brand names, Idarubicin Analogs
Idarubicin Brand Names Mixture
- No information avaliable
Idarubicin Chemical_Formula
C26H27NO9
Idarubicin RX_link
http://www.rxlist.com/cgi/generic2/idarubicin.htm
Idarubicin fda sheet
Idarubicin msds (material safety sheet)
Idarubicin Synthesis Reference
No information avaliable
Idarubicin Molecular Weight
497.494 g/mol
Idarubicin Melting Point
No information avaliable
Idarubicin H2O Solubility
No information avaliable
Idarubicin State
Solid
Idarubicin LogP
0.803
Idarubicin Dosage Forms
Powder for solution
Idarubicin Indication
For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
Idarubicin Pharmacology
Idarubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Idarubicin Absorption
No information avaliable
Idarubicin side effects and Toxicity
No information avaliable
Idarubicin Patient Information
No information avaliable
Idarubicin Organisms Affected
Humans, other mammals and bacteria
