Idarubicin Hydrochloride en es it fr

Idarubicin Hydrochloride Brand names, Idarubicin Hydrochloride Analogs

Idarubicin Hydrochloride Brand Names Mixture

  • No information avaliable

Idarubicin Hydrochloride Chemical_Formula

C26H27NO9

Idarubicin Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/idarubicin.htm

Idarubicin Hydrochloride fda sheet

Idarubicin_Hydrochloride FDA

Idarubicin Hydrochloride msds (material safety sheet)

Idarubicin Hydrochloride Synthesis Reference

No information avaliable

Idarubicin Hydrochloride Molecular Weight

497.494 g/mol

Idarubicin Hydrochloride Melting Point

No information avaliable

Idarubicin Hydrochloride H2O Solubility

No information avaliable

Idarubicin Hydrochloride State

Solid

Idarubicin Hydrochloride LogP

0.803

Idarubicin Hydrochloride Dosage Forms

Powder for solution

Idarubicin Hydrochloride Indication

For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.

Idarubicin Hydrochloride Pharmacology

Idarubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Idarubicin Hydrochloride Absorption

No information avaliable

Idarubicin Hydrochloride side effects and Toxicity

No information avaliable

Idarubicin Hydrochloride Patient Information

No information avaliable

Idarubicin Hydrochloride Organisms Affected

Humans, other mammals and bacteria