Idamycin
Idamycin Brand names, Idamycin Analogs
Idamycin Brand Names Mixture
- No information avaliable
Idamycin Chemical_Formula
C26H27NO9
Idamycin RX_link
http://www.rxlist.com/cgi/generic2/idarubicin.htm
Idamycin fda sheet
Idamycin msds (material safety sheet)
Idamycin Synthesis Reference
No information avaliable
Idamycin Molecular Weight
497.494 g/mol
Idamycin Melting Point
No information avaliable
Idamycin H2O Solubility
No information avaliable
Idamycin State
Solid
Idamycin LogP
0.803
Idamycin Dosage Forms
Powder for solution
Idamycin Indication
For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
Idamycin Pharmacology
Idarubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Idamycin Absorption
No information avaliable
Idamycin side effects and Toxicity
No information avaliable
Idamycin Patient Information
No information avaliable
Idamycin Organisms Affected
Humans, other mammals and bacteria
