Gen-xene
Brand names,
Gen-xene
Analogs
Gen-xene
Brand Names Mixture
- Dermadex Crm (Benzoic Acid + Benzyl Benzoate + Lindane + Salicylic Acid + Zinc Oxide + Zinc Undecylenate)
Gen-xene
Chemical_Formula
C16H11ClN2O3
Gen-xene
RX_link
http://www.rxlist.com/cgi/generic2/clorazepate.htm
Gen-xene
fda sheet
Gen-xene
msds (material safety sheet)
Gen-xene
Synthesis Reference
No information avaliable
Gen-xene
Molecular Weight
314.723 g/mol
Gen-xene
Melting Point
No information avaliable
Gen-xene
H2O Solubility
Very soluble
Gen-xene
State
Solid
Gen-xene
LogP
2.327
Gen-xene
Dosage Forms
Tablet (containing either 3.75 mg, 7.5 mg or 15 mg of clorazepate dipotassium for oral administration)
Gen-xene
Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Gen-xene
Pharmacology
Clorazepate is a member of the group of drugs called benzodiazepines. Pharmacologically, clorazepate has the characteristics of the benzodiazepines. It has depressant effects on the central nervous system. The primary metabolite, nordiazepam, quickly appears in the blood stream. Studies in healthy men have shown that clorazenate has depressant effects on the central nervous system. Since orally administered clorazepate dipotassium is rapidly decarboxylated to form nordiazepam, there is essentially no circulating parent drug.
Gen-xene
Absorption
Rapidly absorbed following oral administration (bioavailability is 91%).
Gen-xene
side effects and Toxicity
Oral LD50 in rats is 1320 mg/kg. In monkeys, oral LD50 exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Gen-xene
Patient Information
Gen-xene
Organisms Affected
Humans and other mammals