Clorazepic acid
Brand names,
Clorazepic acid
Analogs
Clorazepic acid
Brand Names Mixture
- Dermadex Crm (Benzoic Acid + Benzyl Benzoate + Lindane + Salicylic Acid + Zinc Oxide + Zinc Undecylenate)
Clorazepic acid
Chemical_Formula
C16H11ClN2O3
Clorazepic acid
RX_link
http://www.rxlist.com/cgi/generic2/clorazepate.htm
Clorazepic acid
fda sheet
Clorazepic acid
msds (material safety sheet)
Clorazepic acid
Synthesis Reference
No information avaliable
Clorazepic acid
Molecular Weight
314.723 g/mol
Clorazepic acid
Melting Point
No information avaliable
Clorazepic acid
H2O Solubility
Very soluble
Clorazepic acid
State
Solid
Clorazepic acid
LogP
2.327
Clorazepic acid
Dosage Forms
Tablet (containing either 3.75 mg, 7.5 mg or 15 mg of clorazepate dipotassium for oral administration)
Clorazepic acid
Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Clorazepic acid
Pharmacology
Clorazepate is a member of the group of drugs called benzodiazepines. Pharmacologically, clorazepate has the characteristics of the benzodiazepines. It has depressant effects on the central nervous system. The primary metabolite, nordiazepam, quickly appears in the blood stream. Studies in healthy men have shown that clorazenate has depressant effects on the central nervous system. Since orally administered clorazepate dipotassium is rapidly decarboxylated to form nordiazepam, there is essentially no circulating parent drug.
Clorazepic acid
Absorption
Rapidly absorbed following oral administration (bioavailability is 91%).
Clorazepic acid
side effects and Toxicity
Oral LD50 in rats is 1320 mg/kg. In monkeys, oral LD50 exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Clorazepic acid
Patient Information
Clorazepic acid
Organisms Affected
Humans and other mammals