Chlorazepate
Chlorazepate Brand names, Chlorazepate Analogs
Chlorazepate Brand Names Mixture
- Dermadex Crm (Benzoic Acid + Benzyl Benzoate + Lindane + Salicylic Acid + Zinc Oxide + Zinc Undecylenate)
Chlorazepate Chemical_Formula
C16H11ClN2O3
Chlorazepate RX_link
http://www.rxlist.com/cgi/generic2/clorazepate.htm
Chlorazepate fda sheet
Chlorazepate msds (material safety sheet)
Chlorazepate Synthesis Reference
No information avaliable
Chlorazepate Molecular Weight
314.723 g/mol
Chlorazepate Melting Point
No information avaliable
Chlorazepate H2O Solubility
Very soluble
Chlorazepate State
Solid
Chlorazepate LogP
2.327
Chlorazepate Dosage Forms
Tablet (containing either 3.75 mg, 7.5 mg or 15 mg of clorazepate dipotassium for oral administration)
Chlorazepate Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Chlorazepate Pharmacology
Clorazepate is a member of the group of drugs called benzodiazepines. Pharmacologically, clorazepate has the characteristics of the benzodiazepines. It has depressant effects on the central nervous system. The primary metabolite, nordiazepam, quickly appears in the blood stream. Studies in healthy men have shown that clorazenate has depressant effects on the central nervous system. Since orally administered clorazepate dipotassium is rapidly decarboxylated to form nordiazepam, there is essentially no circulating parent drug.
Chlorazepate Absorption
Rapidly absorbed following oral administration (bioavailability is 91%).
Chlorazepate side effects and Toxicity
Oral LD50 in rats is 1320 mg/kg. In monkeys, oral LD50 exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Chlorazepate Patient Information
Chlorazepate Organisms Affected
Humans and other mammals
