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Flovacil Brand names, Flovacil Analogs

Flovacil Brand Names Mixture

  • No information avaliable

Flovacil Chemical_Formula

C13H8F2O3

Flovacil RX_link

http://www.rxlist.com/cgi/generic3/diflunisal.htm

Flovacil fda sheet

Flovacil msds (material safety sheet)

Flovacil MSDS

Flovacil Synthesis Reference

No information avaliable

Flovacil Molecular Weight

250.198 g/mol

Flovacil Melting Point

210-221 oC

Flovacil H2O Solubility

Practically insoluble (14.5 mg/L) at neutral or acidic pH.

Flovacil State

Solid

Flovacil LogP

3.876

Flovacil Dosage Forms

Tablets for oral administration (250 mg or 500 mg)

Flovacil Indication

For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

Flovacil Pharmacology

Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.

Flovacil Absorption

Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.

Flovacil side effects and Toxicity

Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.

Flovacil Patient Information

Flovacil Organisms Affected

Humans and other mammals