Dolisal en es it fr

Dolisal Brand names, Dolisal Analogs

Dolisal Brand Names Mixture

  • No information avaliable

Dolisal Chemical_Formula


Dolisal RX_link

Dolisal fda sheet

Dolisal msds (material safety sheet)

Dolisal MSDS

Dolisal Synthesis Reference

No information avaliable

Dolisal Molecular Weight

250.198 g/mol

Dolisal Melting Point

210-221 oC

Dolisal H2O Solubility

Practically insoluble (14.5 mg/L) at neutral or acidic pH.

Dolisal State


Dolisal LogP


Dolisal Dosage Forms

Tablets for oral administration (250 mg or 500 mg)

Dolisal Indication

For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

Dolisal Pharmacology

Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.

Dolisal Absorption

Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.

Dolisal side effects and Toxicity

Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.

Dolisal Patient Information

Dolisal Organisms Affected

Humans and other mammals