Dolisal

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase Inhibitors
• ATC:N02BA11

• Adomal
• Difludol
• Dolisal
• Dolobid
• Dolobil
• Dolobis
• Flovacil
• Fluniget
• Fluodonil
• Flustar

• No information avaliable

C₁₃H₈F₂O₃

http://www.rxlist.com/cgi/generic3/diflunisal.htm

Dolisal MSDS

No information avaliable

250.198 g/mol

210-221 ^oC

Practically insoluble (14.5 mg/L) at neutral or acidic pH.

Solid

3.876

Tablets for oral administration (250 mg or 500 mg)

For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.

Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.

Oral LD₅₀ in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.

Humans and other mammals