Fluniget
Fluniget Brand names, Fluniget Analogs
Fluniget Brand Names Mixture
- No information avaliable
Fluniget Chemical_Formula
C13H8F2O3
Fluniget RX_link
http://www.rxlist.com/cgi/generic3/diflunisal.htm
Fluniget fda sheet
Fluniget msds (material safety sheet)
Fluniget Synthesis Reference
No information avaliable
Fluniget Molecular Weight
250.198 g/mol
Fluniget Melting Point
210-221 oC
Fluniget H2O Solubility
Practically insoluble (14.5 mg/L) at neutral or acidic pH.
Fluniget State
Solid
Fluniget LogP
3.876
Fluniget Dosage Forms
Tablets for oral administration (250 mg or 500 mg)
Fluniget Indication
For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.
Fluniget Pharmacology
Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.
Fluniget Absorption
Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.
Fluniget side effects and Toxicity
Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.
Fluniget Patient Information
Fluniget Organisms Affected
Humans and other mammals
