Dolobis en es it fr

Dolobis Brand names, Dolobis Analogs

Dolobis Brand Names Mixture

  • No information avaliable

Dolobis Chemical_Formula


Dolobis RX_link

Dolobis fda sheet

Dolobis msds (material safety sheet)

Dolobis MSDS

Dolobis Synthesis Reference

No information avaliable

Dolobis Molecular Weight

250.198 g/mol

Dolobis Melting Point

210-221 oC

Dolobis H2O Solubility

Practically insoluble (14.5 mg/L) at neutral or acidic pH.

Dolobis State


Dolobis LogP


Dolobis Dosage Forms

Tablets for oral administration (250 mg or 500 mg)

Dolobis Indication

For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

Dolobis Pharmacology

Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.

Dolobis Absorption

Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.

Dolobis side effects and Toxicity

Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.

Dolobis Patient Information

Dolobis Organisms Affected

Humans and other mammals