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Adomal Brand names, Adomal Analogs

Adomal Brand Names Mixture

  • No information avaliable

Adomal Chemical_Formula

C13H8F2O3

Adomal RX_link

http://www.rxlist.com/cgi/generic3/diflunisal.htm

Adomal fda sheet

Adomal msds (material safety sheet)

Adomal MSDS

Adomal Synthesis Reference

No information avaliable

Adomal Molecular Weight

250.198 g/mol

Adomal Melting Point

210-221 oC

Adomal H2O Solubility

Practically insoluble (14.5 mg/L) at neutral or acidic pH.

Adomal State

Solid

Adomal LogP

3.876

Adomal Dosage Forms

Tablets for oral administration (250 mg or 500 mg)

Adomal Indication

For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

Adomal Pharmacology

Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure.

Adomal Absorption

Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%.

Adomal side effects and Toxicity

Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.

Adomal Patient Information

Adomal Organisms Affected

Humans and other mammals