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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C16H21N3
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
255.358 g/mol
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Melting Point
No information avaliable
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H2O Solubility
587 mg/L
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State
Solid
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LogP
2.646
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Dosage Forms
Cream; Liquid; Tablet
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Indication
Used for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold.
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Pharmacology
Used to treat the effects of colds and allergies. Tripelennamine is an antihistamine. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
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Absorption
Well absorbed in the digestive tract.
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side effects and Toxicity
Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands and trouble in sleeping.
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Patient Information
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Organisms Affected
Humans and other mammals