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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C22H30N2O2S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
386.552 g/mol
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Melting Point
97 oC
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H2O Solubility
76 mg/L
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State
Solid
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LogP
3.382
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Dosage Forms
Liquid; Solution
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Indication
Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
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Pharmacology
Sufentanil is a synthetic opioid analgesic. Sufentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Sufentanil may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Sufentanil depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
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Absorption
No information avaliable
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side effects and Toxicity
LD50: 18.7 mg/kg (IV in mice)
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Patient Information
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Organisms Affected
Humans and other mammals