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CPT Brand names, CPT Analogs

CPT Brand Names Mixture

  • No information avaliable

CPT Chemical_Formula

C33H38N4O6

CPT RX_link

http://www.rxlist.com/cgi/generic2/irinot.htm

CPT fda sheet

CPT FDA

CPT msds (material safety sheet)

CPT MSDS

CPT Synthesis Reference

T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)

CPT Molecular Weight

586.678 g/mol

CPT Melting Point

222-223 oC

CPT H2O Solubility

Soluble

CPT State

Solid

CPT LogP

4.372

CPT Dosage Forms

Solution for IM injection

CPT Indication

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).

CPT Pharmacology

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).

CPT Absorption

100%

CPT side effects and Toxicity

Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.

CPT Patient Information

CPT Organisms Affected

Humans and other mammals