CPT
CPT Brand names, CPT Analogs
CPT Brand Names Mixture
- No information avaliable
CPT Chemical_Formula
C33H38N4O6
CPT RX_link
http://www.rxlist.com/cgi/generic2/irinot.htm
CPT fda sheet
CPT msds (material safety sheet)
CPT Synthesis Reference
T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)
CPT Molecular Weight
586.678 g/mol
CPT Melting Point
222-223 oC
CPT H2O Solubility
Soluble
CPT State
Solid
CPT LogP
4.372
CPT Dosage Forms
Solution for IM injection
CPT Indication
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).
CPT Pharmacology
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).
CPT Absorption
100%
CPT side effects and Toxicity
Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.
CPT Patient Information
CPT Organisms Affected
Humans and other mammals
