Irinotecan Hcl
Irinotecan Hcl Brand names, Irinotecan Hcl Analogs
Irinotecan Hcl Brand Names Mixture
- No information avaliable
Irinotecan Hcl Chemical_Formula
C33H38N4O6
Irinotecan Hcl RX_link
http://www.rxlist.com/cgi/generic2/irinot.htm
Irinotecan Hcl fda sheet
Irinotecan Hcl msds (material safety sheet)
Irinotecan Hcl Synthesis Reference
T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)
Irinotecan Hcl Molecular Weight
586.678 g/mol
Irinotecan Hcl Melting Point
222-223 oC
Irinotecan Hcl H2O Solubility
Soluble
Irinotecan Hcl State
Solid
Irinotecan Hcl LogP
4.372
Irinotecan Hcl Dosage Forms
Solution for IM injection
Irinotecan Hcl Indication
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).
Irinotecan Hcl Pharmacology
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).
Irinotecan Hcl Absorption
100%
Irinotecan Hcl side effects and Toxicity
Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.
Irinotecan Hcl Patient Information
Irinotecan Hcl Organisms Affected
Humans and other mammals
