Irinotecan Hcl en es it fr

Irinotecan Hcl Brand names, Irinotecan Hcl Analogs

Irinotecan Hcl Brand Names Mixture

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Irinotecan Hcl Chemical_Formula


Irinotecan Hcl RX_link

Irinotecan Hcl fda sheet

Irinotecan_Hcl FDA

Irinotecan Hcl msds (material safety sheet)

Irinotecan_Hcl MSDS

Irinotecan Hcl Synthesis Reference

T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)

Irinotecan Hcl Molecular Weight

586.678 g/mol

Irinotecan Hcl Melting Point

222-223 oC

Irinotecan Hcl H2O Solubility


Irinotecan Hcl State


Irinotecan Hcl LogP


Irinotecan Hcl Dosage Forms

Solution for IM injection

Irinotecan Hcl Indication

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).

Irinotecan Hcl Pharmacology

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).

Irinotecan Hcl Absorption


Irinotecan Hcl side effects and Toxicity

Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.

Irinotecan Hcl Patient Information

Irinotecan Hcl Organisms Affected

Humans and other mammals