Irinotecan Hydrochloride
Irinotecan Hydrochloride Brand names, Irinotecan Hydrochloride Analogs
Irinotecan Hydrochloride Brand Names Mixture
- No information avaliable
Irinotecan Hydrochloride Chemical_Formula
C33H38N4O6
Irinotecan Hydrochloride RX_link
http://www.rxlist.com/cgi/generic2/irinot.htm
Irinotecan Hydrochloride fda sheet
Irinotecan Hydrochloride msds (material safety sheet)
Irinotecan Hydrochloride Synthesis Reference
T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)
Irinotecan Hydrochloride Molecular Weight
586.678 g/mol
Irinotecan Hydrochloride Melting Point
222-223 oC
Irinotecan Hydrochloride H2O Solubility
Soluble
Irinotecan Hydrochloride State
Solid
Irinotecan Hydrochloride LogP
4.372
Irinotecan Hydrochloride Dosage Forms
Solution for IM injection
Irinotecan Hydrochloride Indication
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).
Irinotecan Hydrochloride Pharmacology
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).
Irinotecan Hydrochloride Absorption
100%
Irinotecan Hydrochloride side effects and Toxicity
Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.
Irinotecan Hydrochloride Patient Information
Irinotecan Hydrochloride Organisms Affected
Humans and other mammals
