PharmacyCodes



Irinotecanum [Inn-Latin] en es it fr

Irinotecanum [Inn-Latin] Brand names, Irinotecanum [Inn-Latin] Analogs

Irinotecanum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Irinotecanum [Inn-Latin] Chemical_Formula

C33H38N4O6

Irinotecanum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/irinot.htm

Irinotecanum [Inn-Latin] fda sheet

Irinotecanum_[Inn-Latin] FDA

Irinotecanum [Inn-Latin] msds (material safety sheet)

Irinotecanum_[Inn-Latin] MSDS

Irinotecanum [Inn-Latin] Synthesis Reference

T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)

Irinotecanum [Inn-Latin] Molecular Weight

586.678 g/mol

Irinotecanum [Inn-Latin] Melting Point

222-223 oC

Irinotecanum [Inn-Latin] H2O Solubility

Soluble

Irinotecanum [Inn-Latin] State

Solid

Irinotecanum [Inn-Latin] LogP

4.372

Irinotecanum [Inn-Latin] Dosage Forms

Solution for IM injection

Irinotecanum [Inn-Latin] Indication

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).

Irinotecanum [Inn-Latin] Pharmacology

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).

Irinotecanum [Inn-Latin] Absorption

100%

Irinotecanum [Inn-Latin] side effects and Toxicity

Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.

Irinotecanum [Inn-Latin] Patient Information

Irinotecanum [Inn-Latin] Organisms Affected

Humans and other mammals