Irinotecan Hydrochloride Trihydrate

Irinotecan Hydrochloride Trihydrate Brand names, Irinotecan Hydrochloride Trihydrate Analogs

Irinotecan Hydrochloride Trihydrate Brand Names Mixture

No information avaliable

Irinotecan Hydrochloride Trihydrate Chemical_Formula

C₃₃H₃₈N₄O₆

Irinotecan Hydrochloride Trihydrate RX_link

http://www.rxlist.com/cgi/generic2/irinot.htm

Irinotecan Hydrochloride Trihydrate fda sheet

Irinotecan_Hydrochloride_Trihydrate FDA

Irinotecan Hydrochloride Trihydrate msds (material safety sheet)

Irinotecan_Hydrochloride_Trihydrate MSDS

Irinotecan Hydrochloride Trihydrate Synthesis Reference

T. Miyasaka et al., U.S. pat. 4,604,463 (1985, 1986 both to Yakult Honsha)

Irinotecan Hydrochloride Trihydrate Molecular Weight

586.678 g/mol

Irinotecan Hydrochloride Trihydrate Melting Point

222-223 ^oC

Irinotecan Hydrochloride Trihydrate H₂O Solubility

Soluble

Irinotecan Hydrochloride Trihydrate State

Solid

Irinotecan Hydrochloride Trihydrate LogP

4.372

Irinotecan Hydrochloride Trihydrate Dosage Forms

Solution for IM injection

Irinotecan Hydrochloride Trihydrate Indication

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin).

Irinotecan Hydrochloride Trihydrate Pharmacology

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of Irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of Irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).

Irinotecan Hydrochloride Trihydrate Absorption

100%

Irinotecan Hydrochloride Trihydrate side effects and Toxicity

Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.

Irinotecan Hydrochloride Trihydrate Patient Information

Irinotecan Hydrochloride Trihydrate Organisms Affected

Humans and other mammals