Bupropion
Bupropion Brand names, Bupropion Analogs
Bupropion Brand Names Mixture
- No information avaliable
Bupropion Chemical_Formula
C13H18ClNO
Bupropion RX_link
http://www.rxlist.com/cgi/generic/bupropz.htm
Bupropion fda sheet
Bupropion msds (material safety sheet)
Bupropion Synthesis Reference
N. B. Mehta, U.S. Pat.. 3,819,706 and 3,885,046 (1974,1975)
Bupropion Molecular Weight
239.741 g/mol
Bupropion Melting Point
233-234oC
Bupropion H2O Solubility
312 mg/ml
Bupropion State
Solid
Bupropion LogP
3.741
Bupropion Dosage Forms
Immediate and sustained release tablets
Bupropion Indication
For the treatment of depression and as aid to smoking cessation.
Bupropion Pharmacology
Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine. In addition, Bupropion does not inhibit monoamine oxidase. Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.
Bupropion Absorption
For sustained release, peak plasma concentrations are achieved within 3 hours.
Bupropion side effects and Toxicity
Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Bupropion Patient Information
Bupropion Organisms Affected
Humans and other mammals
