Wellbutrin Sr
Brand names,
Wellbutrin Sr
Analogs
Wellbutrin Sr
Brand Names Mixture
Wellbutrin Sr
Chemical_Formula
C13H18ClNO
Wellbutrin Sr
RX_link
http://www.rxlist.com/cgi/generic/bupropz.htm
Wellbutrin Sr
fda sheet
Wellbutrin Sr
msds (material safety sheet)
Wellbutrin Sr
Synthesis Reference
N. B. Mehta, U.S. Pat.. 3,819,706 and 3,885,046 (1974,1975)
Wellbutrin Sr
Molecular Weight
239.741 g/mol
Wellbutrin Sr
Melting Point
233-234oC
Wellbutrin Sr
H2O Solubility
312 mg/ml
Wellbutrin Sr
State
Solid
Wellbutrin Sr
LogP
3.741
Wellbutrin Sr
Dosage Forms
Immediate and sustained release tablets
Wellbutrin Sr
Indication
For the treatment of depression and as aid to smoking cessation.
Wellbutrin Sr
Pharmacology
Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine. In addition, Bupropion does not inhibit monoamine oxidase. Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.
Wellbutrin Sr
Absorption
For sustained release, peak plasma concentrations are achieved within 3 hours.
Wellbutrin Sr
side effects and Toxicity
Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Wellbutrin Sr
Patient Information
Wellbutrin Sr
Organisms Affected
Humans and other mammals