Zyban
Zyban Brand names, Zyban Analogs
Zyban Brand Names Mixture
- No information avaliable
Zyban Chemical_Formula
C13H18ClNO
Zyban RX_link
http://www.rxlist.com/cgi/generic/bupropz.htm
Zyban fda sheet
Zyban msds (material safety sheet)
Zyban Synthesis Reference
N. B. Mehta, U.S. Pat.. 3,819,706 and 3,885,046 (1974,1975)
Zyban Molecular Weight
239.741 g/mol
Zyban Melting Point
233-234oC
Zyban H2O Solubility
312 mg/ml
Zyban State
Solid
Zyban LogP
3.741
Zyban Dosage Forms
Immediate and sustained release tablets
Zyban Indication
For the treatment of depression and as aid to smoking cessation.
Zyban Pharmacology
Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine. In addition, Bupropion does not inhibit monoamine oxidase. Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.
Zyban Absorption
For sustained release, peak plasma concentrations are achieved within 3 hours.
Zyban side effects and Toxicity
Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Zyban Patient Information
Zyban Organisms Affected
Humans and other mammals
