Buprenorfina [Inn-Spanish]
Brand names,
Buprenorfina [Inn-Spanish]
Analogs
Buprenorfina [Inn-Spanish]
Brand Names Mixture
Buprenorfina [Inn-Spanish]
Chemical_Formula
C29H41NO4
Buprenorfina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic3/suboxone.htm
Buprenorfina [Inn-Spanish]
fda sheet
Buprenorfina [Inn-Spanish]
msds (material safety sheet)
Buprenorfina [Inn-Spanish]
Synthesis Reference
No information avaliable
Buprenorfina [Inn-Spanish]
Molecular Weight
467.64 g/mol
Buprenorfina [Inn-Spanish]
Melting Point
No information avaliable
Buprenorfina [Inn-Spanish]
H2O Solubility
No information avaliable
Buprenorfina [Inn-Spanish]
State
Solid
Buprenorfina [Inn-Spanish]
LogP
5.096
Buprenorfina [Inn-Spanish]
Dosage Forms
Tablet (sublingual)
Buprenorfina [Inn-Spanish]
Indication
For the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
Buprenorfina [Inn-Spanish]
Pharmacology
Buprenorphine is a synthetic opioid analgesic and thebaine derivative, with a longer duration of action than morphine. Buprenorphine interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, buprenorphine exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Buprenorphine may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Buprenorphine depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Buprenorfina [Inn-Spanish]
Absorption
31% bioavailability (sublingual)
Buprenorfina [Inn-Spanish]
side effects and Toxicity
Manifestations of acute overdose include pinpoint pupils, sedation, hypotension, respiratory depression and death.
Buprenorfina [Inn-Spanish]
Patient Information
Buprenorfina [Inn-Spanish]
Organisms Affected
Humans and other mammals