Allergefon
Brand names,
Allergefon
Analogs
Allergefon
Brand Names Mixture
Allergefon
Chemical_Formula
C16H19ClN2O
Allergefon
RX_link
http://www.rxlist.com/cgi/generic3/rondecsyr.htm
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fda sheet
Allergefon
msds (material safety sheet)
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Synthesis Reference
No information avaliable
Allergefon
Molecular Weight
290.788 g/mol
Allergefon
Melting Point
< 25 oC
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H2O Solubility
No information avaliable
Allergefon
State
Liquid
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LogP
2.979
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Dosage Forms
Oral drops; Syrup; Tablet
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Indication
For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis.
Allergefon
Pharmacology
Carbinoxamine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, carbinoxamine competes with free histamine for binding at HA-receptor sites. Carbinoxamine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of carbinoxamine.
Allergefon
Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals