Abbott 84538 en es it fr

Abbott 84538 Brand names, Abbott 84538 Analogs

Abbott 84538 Brand Names Mixture

  • Kaletra (Lopinavir + Ritonavir)

Abbott 84538 Chemical_Formula


Abbott 84538 RX_link

Abbott 84538 fda sheet

Abbott_84538 FDA

Abbott 84538 msds (material safety sheet)

Abbott_84538 MSDS

Abbott 84538 Synthesis Reference

No information avaliable

Abbott 84538 Molecular Weight

720.946 g/mol

Abbott 84538 Melting Point

No information avaliable

Abbott 84538 H2O Solubility

Practically insoluble

Abbott 84538 State


Abbott 84538 LogP


Abbott 84538 Dosage Forms

Capsule (100 mg); Solution (80 mg/mL of ritonavir)

Abbott 84538 Indication

Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.

Abbott 84538 Pharmacology

Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Abbott 84538 Absorption

The absolute bioavailability of ritonavir has not been determined.

Abbott 84538 side effects and Toxicity

Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.

Abbott 84538 Patient Information

No information avaliable

Abbott 84538 Organisms Affected

Human immunodeficiency virus