Abbott 84538
Abbott 84538 Brand names, Abbott 84538 Analogs
Abbott 84538 Brand Names Mixture
- Kaletra (Lopinavir + Ritonavir)
Abbott 84538 Chemical_Formula
C37H48N6O5S2
Abbott 84538 RX_link
http://www.rxlist.com/cgi/generic2/ritonavirsol.htm
Abbott 84538 fda sheet
Abbott 84538 msds (material safety sheet)
Abbott 84538 Synthesis Reference
No information avaliable
Abbott 84538 Molecular Weight
720.946 g/mol
Abbott 84538 Melting Point
No information avaliable
Abbott 84538 H2O Solubility
Practically insoluble
Abbott 84538 State
Solid
Abbott 84538 LogP
4.941
Abbott 84538 Dosage Forms
Capsule (100 mg); Solution (80 mg/mL of ritonavir)
Abbott 84538 Indication
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Abbott 84538 Pharmacology
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Abbott 84538 Absorption
The absolute bioavailability of ritonavir has not been determined.
Abbott 84538 side effects and Toxicity
Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.
Abbott 84538 Patient Information
No information avaliable
Abbott 84538 Organisms Affected
Human immunodeficiency virus
