Norvir Sec
Norvir Sec Brand names, Norvir Sec Analogs
Norvir Sec Brand Names Mixture
- Kaletra (Lopinavir + Ritonavir)
Norvir Sec Chemical_Formula
C37H48N6O5S2
Norvir Sec RX_link
http://www.rxlist.com/cgi/generic2/ritonavirsol.htm
Norvir Sec fda sheet
Norvir Sec msds (material safety sheet)
Norvir Sec Synthesis Reference
No information avaliable
Norvir Sec Molecular Weight
720.946 g/mol
Norvir Sec Melting Point
No information avaliable
Norvir Sec H2O Solubility
Practically insoluble
Norvir Sec State
Solid
Norvir Sec LogP
4.941
Norvir Sec Dosage Forms
Capsule (100 mg); Solution (80 mg/mL of ritonavir)
Norvir Sec Indication
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Norvir Sec Pharmacology
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Norvir Sec Absorption
The absolute bioavailability of ritonavir has not been determined.
Norvir Sec side effects and Toxicity
Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.
Norvir Sec Patient Information
No information avaliable
Norvir Sec Organisms Affected
Human immunodeficiency virus
