PharmacyCodes



Ritonavir [Usan] en es it fr

Ritonavir [Usan] Brand names, Ritonavir [Usan] Analogs

Ritonavir [Usan] Brand Names Mixture

  • Kaletra (Lopinavir + Ritonavir)

Ritonavir [Usan] Chemical_Formula

C37H48N6O5S2

Ritonavir [Usan] RX_link

http://www.rxlist.com/cgi/generic2/ritonavirsol.htm

Ritonavir [Usan] fda sheet

Ritonavir_[Usan] FDA

Ritonavir [Usan] msds (material safety sheet)

Ritonavir_[Usan] MSDS

Ritonavir [Usan] Synthesis Reference

No information avaliable

Ritonavir [Usan] Molecular Weight

720.946 g/mol

Ritonavir [Usan] Melting Point

No information avaliable

Ritonavir [Usan] H2O Solubility

Practically insoluble

Ritonavir [Usan] State

Solid

Ritonavir [Usan] LogP

4.941

Ritonavir [Usan] Dosage Forms

Capsule (100 mg); Solution (80 mg/mL of ritonavir)

Ritonavir [Usan] Indication

Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.

Ritonavir [Usan] Pharmacology

Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Ritonavir [Usan] Absorption

The absolute bioavailability of ritonavir has not been determined.

Ritonavir [Usan] side effects and Toxicity

Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.

Ritonavir [Usan] Patient Information

No information avaliable

Ritonavir [Usan] Organisms Affected

Human immunodeficiency virus