Norvir
Norvir Brand names, Norvir Analogs
Norvir Brand Names Mixture
- Kaletra (Lopinavir + Ritonavir)
Norvir Chemical_Formula
C37H48N6O5S2
Norvir RX_link
http://www.rxlist.com/cgi/generic2/ritonavirsol.htm
Norvir fda sheet
Norvir msds (material safety sheet)
Norvir Synthesis Reference
No information avaliable
Norvir Molecular Weight
720.946 g/mol
Norvir Melting Point
No information avaliable
Norvir H2O Solubility
Practically insoluble
Norvir State
Solid
Norvir LogP
4.941
Norvir Dosage Forms
Capsule (100 mg); Solution (80 mg/mL of ritonavir)
Norvir Indication
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Norvir Pharmacology
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Norvir Absorption
The absolute bioavailability of ritonavir has not been determined.
Norvir side effects and Toxicity
Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.
Norvir Patient Information
No information avaliable
Norvir Organisms Affected
Human immunodeficiency virus
