Solage
Category
Solage Brand names, Solage Analogs
Solage Brand Names Mixture
No information avaliable
Solage Chemical_Formula
C20H28O2
Solage RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Solage fda sheet
Solage msds (material safety sheet)
Solage Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Solage Molecular Weight
300.435 g/mol
Solage Melting Point
181 oC
Solage H2O Solubility
<0.1 g/100 mL
Solage State
Solid
Solage LogP
5.067
Solage Dosage Forms
Capsule; Cream; Gel; Liquid
Solage Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Solage Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Solage Absorption
1-31% (topical);
Solage Toxicity
No information avaliable
Solage Patient Information
No information avaliable
Solage Organisms Affected
Humans and other mammals
