Aberel
Category
Aberel Brand names, Aberel Analogs
Aberel Brand Names Mixture
No information avaliable
Aberel Chemical_Formula
C20H28O2
Aberel RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Aberel fda sheet
Aberel msds (material safety sheet)
Aberel Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Aberel Molecular Weight
300.435 g/mol
Aberel Melting Point
181 oC
Aberel H2O Solubility
<0.1 g/100 mL
Aberel State
Solid
Aberel LogP
5.067
Aberel Dosage Forms
Capsule; Cream; Gel; Liquid
Aberel Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Aberel Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Aberel Absorption
1-31% (topical);
Aberel Toxicity
No information avaliable
Aberel Patient Information
No information avaliable
Aberel Organisms Affected
Humans and other mammals
