Aknoten
Category
Aknoten Brand names, Aknoten Analogs
Aknoten Brand Names Mixture
No information avaliable
Aknoten Chemical_Formula
C20H28O2
Aknoten RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Aknoten fda sheet
Aknoten msds (material safety sheet)
Aknoten Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Aknoten Molecular Weight
300.435 g/mol
Aknoten Melting Point
181 oC
Aknoten H2O Solubility
<0.1 g/100 mL
Aknoten State
Solid
Aknoten LogP
5.067
Aknoten Dosage Forms
Capsule; Cream; Gel; Liquid
Aknoten Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Aknoten Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Aknoten Absorption
1-31% (topical);
Aknoten Toxicity
No information avaliable
Aknoten Patient Information
No information avaliable
Aknoten Organisms Affected
Humans and other mammals
