??-Retinoic_Acid
Category
??-Retinoic_Acid Brand names, ??-Retinoic_Acid Analogs
??-Retinoic_Acid Brand Names Mixture
No information avaliable
??-Retinoic_Acid Chemical_Formula
C20H28O2
??-Retinoic_Acid RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
??-Retinoic_Acid fda sheet
??-Retinoic_Acid msds (material safety sheet)
??-Retinoic_Acid Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
??-Retinoic_Acid Molecular Weight
300.435 g/mol
??-Retinoic_Acid Melting Point
181 oC
??-Retinoic_Acid H2O Solubility
<0.1 g/100 mL
??-Retinoic_Acid State
Solid
??-Retinoic_Acid LogP
5.067
??-Retinoic_Acid Dosage Forms
Capsule; Cream; Gel; Liquid
??-Retinoic_Acid Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
??-Retinoic_Acid Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
??-Retinoic_Acid Absorption
1-31% (topical);
??-Retinoic_Acid Toxicity
No information avaliable
??-Retinoic_Acid Patient Information
No information avaliable
??-Retinoic_Acid Organisms Affected
Humans and other mammals
