Retionic_Acid
Category
Retionic_Acid Brand names, Retionic_Acid Analogs
Retionic_Acid Brand Names Mixture
No information avaliable
Retionic_Acid Chemical_Formula
C20H28O2
Retionic_Acid RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Retionic_Acid fda sheet
Retionic_Acid msds (material safety sheet)
Retionic_Acid Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Retionic_Acid Molecular Weight
300.435 g/mol
Retionic_Acid Melting Point
181 oC
Retionic_Acid H2O Solubility
<0.1 g/100 mL
Retionic_Acid State
Solid
Retionic_Acid LogP
5.067
Retionic_Acid Dosage Forms
Capsule; Cream; Gel; Liquid
Retionic_Acid Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Retionic_Acid Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Retionic_Acid Absorption
1-31% (topical);
Retionic_Acid Toxicity
No information avaliable
Retionic_Acid Patient Information
No information avaliable
Retionic_Acid Organisms Affected
Humans and other mammals
