Lsotretinoin
Category
Lsotretinoin Brand names, Lsotretinoin Analogs
Lsotretinoin Brand Names Mixture
No information avaliable
Lsotretinoin Chemical_Formula
C20H28O2
Lsotretinoin RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Lsotretinoin fda sheet
Lsotretinoin msds (material safety sheet)
Lsotretinoin Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Lsotretinoin Molecular Weight
300.435 g/mol
Lsotretinoin Melting Point
181 oC
Lsotretinoin H2O Solubility
<0.1 g/100 mL
Lsotretinoin State
Solid
Lsotretinoin LogP
5.067
Lsotretinoin Dosage Forms
Capsule; Cream; Gel; Liquid
Lsotretinoin Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Lsotretinoin Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Lsotretinoin Absorption
1-31% (topical);
Lsotretinoin Toxicity
No information avaliable
Lsotretinoin Patient Information
No information avaliable
Lsotretinoin Organisms Affected
Humans and other mammals
