phosphomycin disodium salt
Brand names,
phosphomycin disodium salt
Analogs
phosphomycin disodium salt
Brand Names Mixture
- Micardis Plus (Hydrochlorothiazide + Telmisartan)
phosphomycin disodium salt
Chemical_Formula
C3H7O4P
phosphomycin disodium salt
RX_link
http://www.rxlist.com/cgi/generic2/fosfomycin.htm
phosphomycin disodium salt
fda sheet
phosphomycin disodium salt
msds (material safety sheet)
phosphomycin disodium salt
Synthesis Reference
No information avaliable
phosphomycin disodium salt
Molecular Weight
138.059 g/mol
phosphomycin disodium salt
Melting Point
94 oC
phosphomycin disodium salt
H2O Solubility
50 mg/mL (Sodium salt)
phosphomycin disodium salt
State
Solid
phosphomycin disodium salt
LogP
-0.912
phosphomycin disodium salt
Dosage Forms
Powder
phosphomycin disodium salt
Indication
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
phosphomycin disodium salt
Pharmacology
Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
phosphomycin disodium salt
Absorption
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
phosphomycin disodium salt
side effects and Toxicity
LD50>5 g/kg (rats). Side effects may include diarrhea
phosphomycin disodium salt
Patient Information
No information avaliable
phosphomycin disodium salt
Organisms Affected
E. coli and other enteric bacteria