Fosfocina
Brand names,
Fosfocina
Analogs
Fosfocina
Brand Names Mixture
- Micardis Plus (Hydrochlorothiazide + Telmisartan)
Fosfocina
Chemical_Formula
C3H7O4P
Fosfocina
RX_link
http://www.rxlist.com/cgi/generic2/fosfomycin.htm
Fosfocina
fda sheet
Fosfocina
msds (material safety sheet)
Fosfocina
Synthesis Reference
No information avaliable
Fosfocina
Molecular Weight
138.059 g/mol
Fosfocina
Melting Point
94 oC
Fosfocina
H2O Solubility
50 mg/mL (Sodium salt)
Fosfocina
State
Solid
Fosfocina
LogP
-0.912
Fosfocina
Dosage Forms
Powder
Fosfocina
Indication
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Fosfocina
Pharmacology
Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Fosfocina
Absorption
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Fosfocina
side effects and Toxicity
LD50>5 g/kg (rats). Side effects may include diarrhea
Fosfocina
Patient Information
No information avaliable
Fosfocina
Organisms Affected
E. coli and other enteric bacteria