Categorie
Captopril
Les marques,
Captopril
Analogs
Captopril
Les marques melange
No information avaliable
Captopril
Formule chimique
C9H15NO3S
Captopril
RX lien
http://www.rxlist.com/cgi/generic/captop.htm
Captopril
FDA fiche
Captopril
msds (fiche de securite des materiaux)
Captopril
Synthese de reference
DW Cushman, le brevet américain. 4,046,889 (1977)
Captopril
Poids moleculaire
217.286 g/mol
Captopril
Point de fusion
106oC
Captopril
H2O Solubilite
Librement soluble
Captopril
Etat
Solid
Captopril
LogP
0.546
Captopril
Formes pharmaceutiques
Tablet (12,5 mg, 25 mg, 50 mg ou 100 mg)
Captopril
Indication
Pour le traitement de l'hypertension. Il peut être utilisé seul ou en association avec des diurétiques thiazidiques.
Captopril
Pharmacologie
Captopril, une enzyme de conversion (IEC), est utilisé pour traiter l'hypertension artérielle, insuffisance cardiaque congestive, et les syndromes rénaux tels que la néphropathie diabétique et la sclérodermie. L'effet indésirable et les limites pharmacocinétiques du captopril stimulé le développement des inhibiteurs de l'ECA énalapril et ultérieures.
Captopril
Absorption
75% sans nourriture (la présence d'aliments dans le tractus gastro-intestinal réduit l'absorption d'environ 30 à 40 pour cent).
Captopril
Toxicite
Les symptômes de surdose comprennent le coma, la léthargie, une pression artérielle basse, de la lenteur et de l'estomac et de l'irritation intestinale et l'hyperactivité.
Captopril
Information pour les patients
Patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema
(e.g., swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing;
hoarseness) and to discontinue therapy.
Patients should be told to report promptly any indication of infection (e.g., sore throat, fever),which may be a
sign of neutropenia, or of progressive edema which might be related to proteinuria and nephrotic syndrome.
All patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in
blood pressure because of reduction in fluid volume. Other causes of volume depletion such as vomiting or diarrhea
may also lead to a fall in blood pressure; patients should be advised to consult with the physician.
Patients should be advised not to use potassium-sparing diuret-ics, potassium supplements or potassium-containing
salt substitutes without consulting their physician.
Patients should be warned against interruption or discontinuation of medication unless instructed by the
physician.
Heart failure patients on captopril therapy should be cautioned against rapid increases in physical activity.
Patients should be informed that captopril should be taken one hour before meals.
Captopril
Organismes affectes
Les humains et autres mammifères