Captopril
Brand names,
Captopril
Analogs
Captopril
Brand Names Mixture
Captopril
Chemical_Formula
C9H15NO3S
Captopril
RX_link
http://www.rxlist.com/cgi/generic/captop.htm
Captopril
fda sheet
Captopril
msds (material safety sheet)
Captopril
Synthesis Reference
D. W. Cushman, U.S. Pat. 4,046,889 (1977)
Captopril
Molecular Weight
217.286 g/mol
Captopril
Melting Point
106oC
Captopril
H2O Solubility
Freely soluble
Captopril
State
Solid
Captopril
LogP
0.546
Captopril
Dosage Forms
Tablet (12.5 mg, 25 mg, 50 mg, or 100 mg)
Captopril
Indication
For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Captopril
Pharmacology
Captopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure, and renal syndromes such as diabetic nephropathy and scleroderma. The adverse effect and pharmacokinetic limitations of captopril stimulated the development enalapril and subsequent ACE inhibitors.
Captopril
Absorption
75% without food (the presence of food in the gastrointestinal tract reduces absorption by about 30 to 40 percent).
Captopril
side effects and Toxicity
Symptoms of overdose include coma, lethargy, low blood pressure, sluggishness, and stomach and intestinal irritation and hyperactivity.
Captopril
Patient Information
Patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema
(e.g., swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing;
hoarseness) and to discontinue therapy.
Patients should be told to report promptly any indication of infection (e.g., sore throat, fever),which may be a
sign of neutropenia, or of progressive edema which might be related to proteinuria and nephrotic syndrome.
All patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in
blood pressure because of reduction in fluid volume. Other causes of volume depletion such as vomiting or diarrhea
may also lead to a fall in blood pressure; patients should be advised to consult with the physician.
Patients should be advised not to use potassium-sparing diuret-ics, potassium supplements or potassium-containing
salt substitutes without consulting their physician.
Patients should be warned against interruption or discontinuation of medication unless instructed by the
physician.
Heart failure patients on captopril therapy should be cautioned against rapid increases in physical activity.
Patients should be informed that captopril should be taken one hour before meals.
Captopril
Organisms Affected
Humans and other mammals