Aceplus

Aceplus Brand names, Aceplus Analogs

Aceplus Brand Names Mixture

No information avaliable

Aceplus Chemical_Formula

C₉H₁₅NO₃S

Aceplus RX_link

http://www.rxlist.com/cgi/generic/captop.htm

Aceplus fda sheet

Aceplus msds (material safety sheet)

Aceplus MSDS

Aceplus Synthesis Reference

D. W. Cushman, U.S. Pat. 4,046,889 (1977)

Aceplus Molecular Weight

217.286 g/mol

Aceplus Melting Point

106^oC

Aceplus H₂O Solubility

Freely soluble

Aceplus State

Solid

Aceplus LogP

0.546

Aceplus Dosage Forms

Tablet (12.5 mg, 25 mg, 50 mg, or 100 mg)

Aceplus Indication

For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Aceplus Pharmacology

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure, and renal syndromes such as diabetic nephropathy and scleroderma. The adverse effect and pharmacokinetic limitations of captopril stimulated the development enalapril and subsequent ACE inhibitors.

Aceplus Absorption

75% without food (the presence of food in the gastrointestinal tract reduces absorption by about 30 to 40 percent).

Aceplus side effects and Toxicity

Symptoms of overdose include coma, lethargy, low blood pressure, sluggishness, and stomach and intestinal irritation and hyperactivity.

Aceplus Patient Information

Patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema (e.g., swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing; hoarseness) and to discontinue therapy.

Patients should be told to report promptly any indication of infection (e.g., sore throat, fever),which may be a sign of neutropenia, or of progressive edema which might be related to proteinuria and nephrotic syndrome.

All patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume. Other causes of volume depletion such as vomiting or diarrhea may also lead to a fall in blood pressure; patients should be advised to consult with the physician.

Patients should be advised not to use potassium-sparing diuret-ics, potassium supplements or potassium-containing salt substitutes without consulting their physician.

Patients should be warned against interruption or discontinuation of medication unless instructed by the physician.

Heart failure patients on captopril therapy should be cautioned against rapid increases in physical activity.

Patients should be informed that captopril should be taken one hour before meals.

Aceplus Organisms Affected

Humans and other mammals