Iso-Bid
Categoria
Iso-Bid Nombres de marca, Iso-Bid Analogos
- Cardio 10
- Cardis
- Carvanil
- Carvasin
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dilatrate
- Dilatrate-SR
- Dinitrosorbide
- Emoper
- Flindix
- Harrical
- IBD 20
- ISD
- ISDN
- Ismotic
- Iso-Bid
- Isochron
- Isoket
- Isorbid;
- Isordil
- Isordil Tembids
- Isosorbide dinitrate(USAN)
- Isostat
- Isotrate
- Korodil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- Resoidan
- Rifloc Retard
- Rigedal
- Sorbangil
- Sorbide T.D.
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidilat
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Tinidil
- Titradose
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Iso-Bid Marca los nombres de mezcla
Iso-Bid Formula quimica
C6H8N2O8
Iso-Bid RX enlace
http://www.rxlist.com/cgi/generic2/isodinit.htm
Iso-Bid FDA hoja
Iso-Bid MSDS (hoja de seguridad de materiales)
Iso-Bid Sintesis de referencia
Goldberg, Acta Physiol. Scand.15, 173 (1948)
Iso-Bid Peso molecular
236.136 g/mol
Iso-Bid Punto de fusion
70 oC
Iso-Bid H2O Solubilidad
1.089 mg / mL
Iso-Bid Estado
Solid
Iso-Bid LogP
-0.53
Iso-Bid Formas de dosificacion
Tableta oral
Iso-Bid Indicacion
Para la prevención de la angina de pecho debido a enfermedad arterial coronaria.
Iso-Bid Farmacologia
Dinitrato de isosorbida es de moderado a nitrato de acción prolongada por vía oral orgánicos utilizados para el alivio y tratamiento profiláctico de la angina de pecho. Se relaja el músculo liso vascular y la dilatación consecuente de las arterias y venas periféricas, especialmente este último. Dilatación de las venas periféricas promueve la acumulación de sangre y disminuye el retorno venoso al corazón, reduciendo así ventricular izquierda diastólica final la presión y la presión capilar pulmonar (precarga). Relajación arteriolar disminuye la resistencia vascular sistémica, presión arterial sistólica y la presión arterial media.
Iso-Bid Absorcion
La absorción de dinitrato tras la administración oral es casi completa, pero la biodisponibilidad es muy variable (10% a 90%), con importante efecto de primer paso metabólico en el hígado. La biodisponibilidad media de dinitrato de isosorbida es aproximadamente un 25%.
Iso-Bid Toxicidad
Los síntomas de sobredosis incluyen disminución del gasto cardíaco e hipotensión.
Iso-Bid Informacion de Pacientes
PATIENT INFORMATION
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Iso-Bid Organismos afectados
Humanos y otros mamíferos
