Isochron
Isochron Brand names, Isochron Analogs
- Cardio 10
- Cardis
- Carvanil
- Carvasin
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dilatrate
- Dilatrate-SR
- Dinitrosorbide
- Emoper
- Flindix
- Harrical
- IBD 20
- ISD
- ISDN
- Ismotic
- Iso-Bid
- Isochron
- Isoket
- Isorbid;
- Isordil
- Isordil Tembids
- Isosorbide dinitrate(USAN)
- Isostat
- Isotrate
- Korodil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- Resoidan
- Rifloc Retard
- Rigedal
- Sorbangil
- Sorbide T.D.
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidilat
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Tinidil
- Titradose
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Isochron Brand Names Mixture
- No information avaliable
Isochron Chemical_Formula
C6H8N2O8
Isochron RX_link
http://www.rxlist.com/cgi/generic2/isodinit.htm
Isochron fda sheet
Isochron msds (material safety sheet)
Isochron Synthesis Reference
Goldberg, Acta physiol. Scand.15, 173(1948)
Isochron Molecular Weight
236.136 g/mol
Isochron Melting Point
70 oC
Isochron H2O Solubility
1.089 mg/mL
Isochron State
Solid
Isochron LogP
-0.53
Isochron Dosage Forms
Oral tablet
Isochron Indication
For the prevention of angina pectoris due to coronary artery disease.
Isochron Pharmacology
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.
Isochron Absorption
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.
Isochron side effects and Toxicity
Symptoms of overdose include reduced cardiac output and hypotension.
Isochron Patient Information
PATIENT INFORMATION
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Isochron Organisms Affected
Humans and other mammals
