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Cardio 10 Brand names, Cardio 10 Analogs

Cardio 10 Brand Names Mixture

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Cardio 10 Chemical_Formula


Cardio 10 RX_link

Cardio 10 fda sheet

Cardio 10 msds (material safety sheet)

Cardio 10 Synthesis Reference

Goldberg, Acta physiol. Scand.15, 173(1948)

Cardio 10 Molecular Weight

236.136 g/mol

Cardio 10 Melting Point

70 oC

Cardio 10 H2O Solubility

1.089 mg/mL

Cardio 10 State


Cardio 10 LogP


Cardio 10 Dosage Forms

Oral tablet

Cardio 10 Indication

For the prevention of angina pectoris due to coronary artery disease.

Cardio 10 Pharmacology

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

Cardio 10 Absorption

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

Cardio 10 side effects and Toxicity

Symptoms of overdose include reduced cardiac output and hypotension.

Cardio 10 Patient Information


Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.

Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol

Cardio 10 Organisms Affected

Humans and other mammals