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Difutrat Brand names, Difutrat Analogs

Difutrat Brand Names Mixture

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Difutrat Chemical_Formula


Difutrat RX_link


Difutrat fda sheet

Difutrat msds (material safety sheet)

Difutrat Synthesis Reference

Goldberg, Acta physiol. Scand.15, 173(1948)

Difutrat Molecular Weight

236.136 g/mol

Difutrat Melting Point

70 oC

Difutrat H2O Solubility

1.089 mg/mL

Difutrat State


Difutrat LogP


Difutrat Dosage Forms

Oral tablet

Difutrat Indication

For the prevention of angina pectoris due to coronary artery disease.

Difutrat Pharmacology

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

Difutrat Absorption

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

Difutrat side effects and Toxicity

Symptoms of overdose include reduced cardiac output and hypotension.

Difutrat Patient Information


Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.

Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol

Difutrat Organisms Affected

Humans and other mammals