Viroptic
Brand names,
Viroptic
Analogs
Viroptic
Brand Names Mixture
Viroptic
Chemical_Formula
C41H42N4O8
Viroptic
RX_link
http://www.rxlist.com/cgi/generic2/verteporfin.htm
Viroptic
fda sheet
Viroptic
msds (material safety sheet)
Viroptic
Synthesis Reference
No information avaliable
Viroptic
Molecular Weight
718.794 g/mol
Viroptic
Melting Point
No information avaliable
Viroptic
H2O Solubility
No information avaliable
Viroptic
State
Solid
Viroptic
LogP
3.743
Viroptic
Dosage Forms
Powder for solution to be mixed for injection (2mg verteporfin/mL reconstituted verteporfin)
Viroptic
Indication
For the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age-related macular degeneration, pathologic myopia or presumed ocular histoplasmosis.
Viroptic
Pharmacology
Verteporfin, otherwise known as benzoporphyrin derivative, is a medication used in conjunction with laser treatment to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Viroptic
Absorption
No information avaliable
Viroptic
side effects and Toxicity
Overdose of drug and/or light in the treated eye may result in nonperfusion of normal retinal vessels with the possibility of severe decrease in vision that could be permanent. An overdose of drug will also result in the prolongation of the period during which the patient remains photosensitive to bright light.
Viroptic
Patient Information
Viroptic
Organisms Affected
Humans and other mammals