Valproic acid USP en es it fr

Valproic acid USP Brand names, Valproic acid USP Analogs

Valproic acid USP Brand Names Mixture

  • No information avaliable

Valproic acid USP Chemical_Formula


Valproic acid USP RX_link

Valproic acid USP fda sheet

Valproic acid USP msds (material safety sheet)

Valproic_acid_USP MSDS

Valproic acid USP Synthesis Reference

Oberreit, Ber.29, 1998 (1896)

Valproic acid USP Molecular Weight

144.211 g/mol

Valproic acid USP Melting Point

120 - 130 oC

Valproic acid USP H2O Solubility

Slightly soluble (1.3 mg/mL)

Valproic acid USP State


Valproic acid USP LogP


Valproic acid USP Dosage Forms

Capsule (250 mg); Syrup (250 mg drug/5mL syrup)

Valproic acid USP Indication

For use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types which include absence seizures.

Valproic acid USP Pharmacology

Valproic Acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. Valproic Acid is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Valproic Acid dissociates to the valproate ion in the gastrointestinal tract. Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection.

Valproic acid USP Absorption

Rapid absorption from gastrointestinal tract.

Valproic acid USP side effects and Toxicity

Oral, mouse: LD50 = 1098 mg/kg; Oral, rat: LD50 = 670 mg/kg. Symptoms of overdose may include coma, extreme drowsiness, and heart problems.

Valproic acid USP Patient Information

Since valproate products may produce CNS depression, especially when combined with another CNS depressant (eg, alcohol), patients should be advised not to engage in hazardous activities, such as driving an automobile or operating dangerous machinery, until it is known that they do not become drowsy from the drug.

Valproic acid USP Organisms Affected

Humans and other mammals