Trimethobenzamide hydrochloride
Brand names,
Trimethobenzamide hydrochloride
Analogs
Trimethobenzamide hydrochloride
Brand Names Mixture
- Alphasel tablets (calcium phosphate [dibasic] + cobalt sulfate + D-alpha tocopheryl acetate + selenium sulfide)
- Previte (neomycin sulfate + selenium sulfide + streptomycin sulfate + vitamin A + vitamin D + vitamin E + vitamin K1)
Trimethobenzamide hydrochloride
Chemical_Formula
C14H12N6O
Trimethobenzamide hydrochloride
RX_link
No information avaliable
Trimethobenzamide hydrochloride
fda sheet
Trimethobenzamide hydrochloride
msds (material safety sheet)
Trimethobenzamide hydrochloride
Synthesis Reference
No information avaliable
Trimethobenzamide hydrochloride
Molecular Weight
280.285 g/mol
Trimethobenzamide hydrochloride
Melting Point
No information avaliable
Trimethobenzamide hydrochloride
H2O Solubility
No information avaliable
Trimethobenzamide hydrochloride
State
Solid
Trimethobenzamide hydrochloride
LogP
2.759
Trimethobenzamide hydrochloride
Dosage Forms
Intravenous (loading dose of 12 to 24 micrograms/kg over 10 minutes followed by a continuous infusion of 0.05 to 0.2 micrograms/kg per minute, adjusted according to response)
Trimethobenzamide hydrochloride
Indication
For short term treatment of acutely decompensated severe chronic heart failure (CHF).
Trimethobenzamide hydrochloride
Pharmacology
Levosimendan is a new Ca2+-sensitizing inotropic agent. Ca2+ sensitizers represent a new class of inotropic agents, which overcome the disadvantages associated with currently available inotropic agents in as they are not associated with an increased risk of arrhythmias, cell injury and death due to Ca2+ overload in myocardial cells; they do not increase the activation energy; and they have the potential to reverse contractile dysfunction under pathophysiologic conditions, such as acidosis or myocardial stunning. Levosimendan has not been approved for use in the U.S. or Canada.
Trimethobenzamide hydrochloride
Absorption
The bioavailability of oral levosimendan is 85 ± 6% in healthy volunteers and 84 ± 4% in patients.
Trimethobenzamide hydrochloride
side effects and Toxicity
No information avaliable
Trimethobenzamide hydrochloride
Patient Information
No information avaliable
Trimethobenzamide hydrochloride
Organisms Affected
Humans and other mammals